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Mitral Valve |
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#### Aims
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We model and simulate the biomechanical behaviour of the elastic **mitral valve soft tissue** in the human heart, subjected to surgical manipulation during and after **annuloplasty** surgery. A segmented mitral valve geometry is meshed and annotated in order for an FEM simulation, and boundary conditions are defined to model the natural forces during the cardiac cycle and the external forces through annuloplasty.
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The HiFlow³-based simulation application is capable of **simulating the post-surgical behavior of the mitral valve**, both with respect to the **closing behavior** and with respect to the **upcoming stress distribution** which indicate potential tissue rupture.
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#### Why using HiFlow³?
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The mitral valve simulation application is build upon the open-source C++ Finite Element toolkit HiFlow³, which allows to **efficiently simulate the post-surgical behavior of the elastic mitral valve**.
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The boundary value problem formulation was reformulated in the weak form, and accordingly implemented in the assembly part of the simulation application. We used 3D Lagrangian Elements (tetrahedra, 12 degrees of freedom per element) with a total resolution of approximately 50.000 degrees of freedom, which roughly corresponds to the imaging resolution.
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#### Researchers
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[Prof. Dr. Vincent Heuveline](https://emcl.iwr.uni-heidelberg.de/index.php?id=vincent_heuveline)
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Dr. Nicolai Schoch (contact person)
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#### Related information
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The respective mitral valve simulation application was developed in the framework of the collaborative research center (SFB/TRR 125) 'Cognition-Guided Surgery' within project I03 '[Functional Modeling and Numerical Simulation](http://www.cognitionguidedsurgery.de/projekte/i03/)', and was used to deliver essential information on the development of a cognitive surgery assistance and simulation system.
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Further information can be found on the [EMCL website](https://emcl.iwr.uni-heidelberg.de/) and on the project page '[Cognition-Guided Surgery](http://www.cognitionguidedsurgery.de/)'.
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#### Publications
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* Schoch, N., Heuveline, V.. **Towards Cognition-Guided Patient-Specific FEM-based Cardiac Surgery Simulation**.
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Accepted for the [Proceedings of the Functional Imaging and Modeling of the Heart (FIMH) 2017](https://fimh2017.joomla.com/), as part of Springer's Lecture Notes in Computer Science (LNCS), 2017.
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Lena Maier-Hein, Swaroop Vedula, Stefanie Speidel, Nassir Navab, Ron Kikinis, Adrian Park, Matthias Eisenmann, Hubertus Feussner, Germain Forestier, Stamatia Giannarou, Makoto Hashizume, Darko Katic, Hannes Kenngott, Michael Kranzfelder, Anand Malpani, Keno März, Thomas Neumuth, Nicolas Padoy, Carla Pugh, Nicolai Schoch, Danail Stoyanov, Russell Taylor, Martin Wagner, Gregory D. Hager and Pierre Jannin
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"Surgical Data Science: Enabling next-generation surgery"
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Joint Workshop Paper (arXiv:1701.06482, 2017) of the Surgical Data Science International Workshop SDS 2016, 2017.
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Nicolai Schoch, Stefanie Speidel, York Sure-Vetter, Vincent Heuveline
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"Towards Semantic Simulation for Patient-Specific Surgery Assistance"
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Online-Proceedings of the Surgical Data Science International Workshop SDS 2016, 2016.
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Nicolai Schoch, Fabian Kißler, Markus Stoll, Sandy Engelhardt, Raffaele de Simone, Ivo Wolf, Rolf Bendl, Vincent Heuveline
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"Comprehensive patient-specific information preprocessing for cardiac surgery simulations"
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Published in the International Journal of Computer Assisted Radiology and Surgery (IJCARS), Special Issue: IPCAI2016, (DOI: 10.1007/s11548-016-1397-0), 2016.
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Nicolai Schoch, Patrick Philipp, Tobias Weller, Sandy Engelhardt, Mykola Volovyk, Andreas Fetzer, Marco Nolden, Raffaele De Simone, Ivo Wolf, Maria Maleshkova, Achim Rettinger, Rudi Studer, and Vincent Heuveline
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"Cognitive tools pipeline for assistance of mitral valve surgery"
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Proceedings of "SPIE. Medical Imaging 2016: Image-Guided Procedures, Robotic Interventions and Modeling", 2016.
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Andreas Fetzer, Jasmin Metzger, Darko Katic, Keno Maerz, Martin Wagner, Patrick Philipp, Sandy Engelhardt, Tobias Weller, Sascha Zelzer, Alfred Michael Franz, Nicolai Schoch, Vincent Heuveline, Maria Maleshkova, Achim Rettinger, Stefanie Speidel, Ivo Wolf, Hannes Kenngott, Arianeb Mehrabi, Beat Mueller-Stich, Lena Maier-Hein, Hans-Peter Meinzer, and Marco Nolden
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"Towards an open-source semantic data infrastructure for integrating clinical and scientific data in cognition-guided surgery"
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Proceedings of "SPIE. Medical Imaging 2016: PACS and Imaging Informatics: Next Generation and Innovations", 2016.
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Nicolai Schoch, Sandy Engelhardt, Raffaele de Simone, Ivo Wolf, Vincent Heuveline
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"High Performance Computing for Cognition-Guided Cardiac Surgery: Soft Tissue Simulation for Mitral Valve Reconstruction in Knowledge-based Surgery Assistance"
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Accepted for Modeling, Simulation and Optimization of Complex Processes, the Proceedings of the 6th International Conference on High-Performance Scientific Computing, 2015.
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Nicolai Schoch, Sandy Engelhardt, Norbert Zimmermann, Stefanie Speidel, Raffaele De Simone, Ivo Wolf, and Vincent Heuveline
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"Integration of a biomechanical simulation for mitral valve reconstruction into a knowledge-based surgery assistance system"
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Proceedings of "SPIE 9415, Medical Imaging 2015: Image-Guided Procedures, Robotic Interventions and Modeling", 2015.
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Nicolai Schoch
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"Towards Cognition-Guided Patient-Specific Numerical Simulation for Cardiac Surgery Assistance" (PhD Thesis)
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Published at the Heidelberg Document Server HeiDOK, (DOI: 10.11588/heidok.00022579), 2017.
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Nicolai Schoch, Fabian Kißler, Markus Stoll, Sandy Engelhardt, Raffaele de Simone, Ivo Wolf, Rolf Bendl, Vincent Heuveline
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"Comprehensive Pre- and Post-Processing for Numerical Simulations in Cardiac Surgery Assistance"
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Preprint Issue (No. 02/2015) of the Preprint Series of the Engineering Mathematics and Computing Lab (EMCL), 2015.
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Nicolai Schoch, Sandy Engelhardt, Norbert Zimmermann, Stefanie Speidel, Raffaele De Simone, Ivo Wolf, and Vincent Heuveline
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"Integration einer Biomechanischen Simulation zur Unterstützung von Mitralklappen-Rekonstruktionen in ein Wissensbasiertes Assistenzsysystem"
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Article in "Tagungsband der CURAC 2014", Deutsche Gesellschaft für Computer- und Roboterassistierte Chirurgie, e.V., 2014. |
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